PodMyCasts manages PodCasts and their synchronization to your Apple iPod. It is in super early stages and I'm not quite sure yet if its going anywhere. For now it is written in Python using PyGTK. If you would like to help out, gimme a shout.
You can check it out via (though I wouldn't expect much yet):
svn co http://dev.joemonti.org/repos/podmycasts-py/trunk podmycasts-py